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CAS 176325-83-0
5-bromo-7-((1r,4r)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine
Codes: MRX-2843-003
Application context (from source-drug indications)
Acute myeloid leukaemiaMRX-2843LeukaemiaMRX-2843Acute lymphoblastic leukaemiaMRX-2843Non-small cell lung cancerMRX-2843Lung cancerMRX-2843Solid tumourMRX-2843
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| MRX-2843 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
MRX-2843→5-bromo-2-chloro-7H-pyrrolo[2,3-d]pyrimidine→(1s,4s)-4-((tert-butyldimethylsilyl)oxy)cyclohexanol→5-bromo-7-((1r,4r)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine→2-cyclopropylethanamine→5-bromo-7-((1r,4r)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-N-(2-cyclopropylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine→(4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid→7-((1r,4r)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-N-(2-cyclopropylethyl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
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