CAS 179474-79-4

1-(3-methoxypropyl)piperidin-4-amine

Codes: PRUC-010

Application context (from source-drug indications)

ConstipationPrucalopride SuccinatePostoperative complicationPrucalopride SuccinateEnteral feeding intolerancePrucalopride SuccinateOpioid-induced constipationPrucalopride SuccinatePainPrucalopride SuccinateIntestinal pseudo-obstructionPrucalopride Succinate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Prucalopride Succinate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Prucalopride SuccinateOriginator routesteps: 7total yield: 12.6 g

3-methoxyaniline→pivaloyl chloride→N-(3-methoxyphenyl)pivalamide→oxirane→N-(2-(2-hydroxyethyl)-3-methoxyphenyl)pivalamide→2,3-dihydrobenzofuran-4-amine→5-chloro-2,3-dihydrobenzofuran-4-amine→7-bromo-5-chloro-2,3-dihydrobenzofuran-4-amine→4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine

Prucalopride SuccinateOptimised routesteps: 11total yield: 1.12 g

4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine→4-amino-2-hydroxybenzoic acid→methyl 4-amino-2-hydroxybenzoate→methyl 4-acetamido-2-hydroxybenzoate→methyl 4-acetamido-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-2-(2-bromoethoxy)-5-chlorobenzoate→methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate→4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide→succinic acid→piperidin-4-one hydrochloride hydrate→1-bromo-3-methoxypropane→1-(3-methoxypropyl)piperidin-4-one

Prucalopride SuccinateOptimised routesteps: 8total yield: 24.6 g

4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine→methyl 4-acetamido-2-hydroxybenzoate→methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate→3-bromoprop-1-ene→methyl 4-acetamido-2-(allyloxy)benzoate→methyl 4-acetamido-3-allyl-2-hydroxybenzoate→methyl 4-acetamido-2-hydroxy-3-(2-oxoethyl)benzoate→methyl 4-acetamido-2-hydroxy-3-(2-hydroxyethyl)benzoate→methyl 4-acetamido-2,3-dihydrobenzofuran-7-carboxylate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	1-(3-Methoxypropyl)-4-piperidinamine Pharmaceutical Intermediates	On request	On request	On request	—

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