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CAS 1802149-87-6
5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one
Codes: AZD-7986-020
Application context (from source-drug indications)
BronchiectasisBrensocatibLung diseaseBrensocatibSinusitisBrensocatibCystic fibrosisBrensocatibHepatic function declineBrensocatibRenal impairmentBrensocatib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Brensocatib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
AZD-7986→5-chlorobenzo[d]oxazol-2(3H)-one→5-chloro-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate→(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid→tert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate→methyl (chlorosulfonyl)carbamate→tert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate→5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamate→(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanenitrile→3-(benzylamino)propan-1-ol→(S)-2-((benzyloxy)methyl)oxirane→(S)-3-(benzyl(3-(benzyloxy)-2-hydroxypropyl)amino)propan-1-ol→(S)-4-benzyl-2-((benzyloxy)methyl)-1,4-oxazepane→tert-butyl (S)-2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate→5,5,5',5'-tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-3-methyl-1,3-benzoxazol-2(3H)-one Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.