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CAS 1825379-70-1
(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol
Codes: IPRA-018
Application context (from source-drug indications)
Type 2 diabetesSitagliptin Phosphate Monohydrate/Ipragliflozin L-ProlineType 2 diabetesIpragliflozin L-ProlineType 1 diabetesIpragliflozin L-ProlineDiabetesIpragliflozin L-ProlineLiver diseaseIpragliflozin L-Proline
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | Tier C — Watch / trade | - |
| Ipragliflozin L-Proline | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(1S,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-((benzyloxy)methyl)-2,7-dioxabicyclo[4.1.0]heptane→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol
2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(1S,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-((benzyloxy)methyl)-2,7-dioxabicyclo[4.1.0]heptane→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol
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