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CAS 1826-67-1
(Vinyl)magnesium bromidevinylmagnesium bromideVinylmagnesium bromide
Codes: (VIII)101438-67-a, (VII)101438-68-a, DARU-032, Pilocarpine Nitrate-024, (IIb)955428-2-a, Molnupiravir-075, Astaxanthin-040
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateHIV infectionDarunavir Ethanolate/RitonavirHIV infectionDarunavir Ethanolate/CobicistatGlaucomaProxodolol hydrochloride/Pilocarpine HydrochlorideHIV infectionDarunavir EthanolatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel闭角型青光眼Pilocarpine HydrochlorideOcular hypertensionPilocarpine HydrochlorideOpen-angle glaucomaPilocarpine Hydrochloride瞳孔缩小Pilocarpine HydrochlorideSjögren's syndromePilocarpine Hydrochloride虹膜炎Pilocarpine HydrochloridePeripheral T-cell lymphomaGolidocitinibEB病毒感染GolidocitinibViral infectionGolidocitinibHistiocytosisGolidocitinib噬血细胞性淋巴组织细胞增多症GolidocitinibInterstitial lung diseaseGolidocitinibCOVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravir营养失调AstaxanthinKnee arthritisAstaxanthinDiabetic neuropathyAstaxanthinStrokeAstaxanthin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Cobicistat | Tier C — Watch / trade | - |
| Proxodolol hydrochloride/Pilocarpine Hydrochloride | Tier C — Watch / trade | - |
| Darunavir Ethanolate | Tier B — Position early | - |
| Paclitaxel | Tier B — Position early | - |
| Pilocarpine Hydrochloride | Tier C — Watch / trade | - |
| Golidocitinib | Tier C — Watch / trade | - |
| Molnupiravir | Tier B — Position early | - |
| Astaxanthin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-Methyl-2-butenal→2-Bromo-3-methylbut-2-enal→(Trimethylsilyl)methyl chloride→3-Bromo-4-methyl-1-(trimethylsilyl)pent-3-en-2-ol→1-[6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-en-1-yl]prop-2-en-1-ol→3-Bromo-4-methylpenta-1,3-diene→3-Methyl-2-cyclohexen-1-one→6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-ene-1-carbaldehyde→(Vinyl)magnesium bromide→2-Isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-ol→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-one→(12aS)-4-Chloro-9,12a,13,13-tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulen-5(1H)-one
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
Proxodolol hydrochloride/Pilocarpine HydrochlorideRoute 1steps: 10total yield: 150mg(Pilocarpine Nitrate (API))
2-(2,2-Dimethoxyethyl)propane-1,3-diol→2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate→(2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate→(2S)-2-Formyl-4,4-dimethoxybutyl acetate→Vinylmagnesium bromide→(2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol→(5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one→(3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one→[(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde→Methylamine→(4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one→(3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
3-Methyl-2-butenal→2-Bromo-3-methylbut-2-enal→(Trimethylsilyl)methyl chloride→3-Bromo-4-methyl-1-(trimethylsilyl)pent-3-en-2-ol→1-[6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-en-1-yl]prop-2-en-1-ol→3-Bromo-4-methylpenta-1,3-diene→3-Methyl-2-cyclohexen-1-one→6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-ene-1-carbaldehyde→(Vinyl)magnesium bromide→2-Isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-ol→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-one→(12aS)-4-Chloro-9,12a,13,13-tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulen-5(1H)-one
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
2-(2,2-Dimethoxyethyl)propane-1,3-diol→2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate→(2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate→(2S)-2-Formyl-4,4-dimethoxybutyl acetate→Vinylmagnesium bromide→(2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol→(5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one→(3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one→[(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde→Methylamine→(4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one→(3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
(2-Nitrophenyl)boronic acid→Chlorido(ethenyl)magnesium→(Vinyl)magnesium bromide→1H-Indol-7-ylboronic acid→7-Nitro-1H-indole
2(S)-(1,1,1-Triphenylmethoxymethyl)oxirane→(Vinyl)magnesium bromide→(2S)-1-(Triphenylmethoxy)pent-4-en-2-ol→(3S)-3-[[tert-Butyl(diphenyl)silyl]oxy]-4-(triphenylmethoxy)butanal→(2S,3aS,9aR)-2-[(Triphenylmethoxy)methyl]-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-one→Iodoform→tert-Butyl[[(2S,4E)-5-iodo-1-(triphenylmethoxy)pent-4-en-2-yl]oxy]diphenylsilane→1-[(1E,4S)-4-Hydroxy-5-(triphenylmethoxy)pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione→1-[(2R,5S)-5-(Trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione→[(2S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl 2-methylpropanoate→2,4(1H,3H)-Pyrimidinedione→2-Methylpropionic anhydride→5'-O-(2-Methylpropanoyl)uridine→Hydroxylamine sulfate
(7E)-6-Methyl-8-(2,6,6-trimethylcyclohex-1-en-1-yl)oct-7-en-2-one→(Vinyl)magnesium bromide→(6E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-1,6-dien-3-ol→(6E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-1,6-dien-3-yl acetate→O15-Acetyl-7,8,11,12-tetrahydroretinol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | ((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates | On request | On request | On request | — |
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