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CAS 183968-79-8

Butyl 4-amino-3-hydroxybenzoate

Codes: (Ib)409139-8-a

Application context (from source-drug indications)

Amyloid polyneuropathyTafamidis MeglumineTransthyretin amyloidosisTafamidis MeglumineAmyloidosisTafamidis MeglumineCardiomyopathyTafamidis MeglumineLight-chain (AL) amyloidosisTafamidis MeglumineFamilial amyloid neuropathyTafamidis Meglumine

Source drugs (routes using this intermediate)

DrugTierExpiry
Tafamidis MeglumineTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Tafamidis MeglumineOptimised routesteps: 1total yield: /
2-Hydroxy-4-methoxycarbonylaniline→Butyl 4-amino-3-hydroxybenzoate→tert-Butyl 4-amino-3-hydroxybenzoate→Phenyl 4-amino-3-hydroxybenzoate→3,5-Dichlorobenzaldehyde→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→tert-Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→Phenyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate

Intermediates available on this site

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