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CAS 187223-15-0
(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
Codes: PASI-006
Application context (from source-drug indications)
Cushing's syndromePasireotide DiaspartatePituitary ACTH hypersecretionPasireotide DiaspartatePost-bariatric hypoglycaemiaPasireotide DiaspartateCarcinoid tumourPasireotide DiaspartateNeuroendocrine tumourPasireotide DiaspartateCluster headachePasireotide Diaspartate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pasireotide Diaspartate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
PASI-001→PASI-002→PASI-003→PASI-004→PASI-005→(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid→PASI-007→PASI-008→PASI-009→(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-((chlorocarbonyl)oxy)pyrrolidine-1,2-dicarboxylate→tert-butyl (2-aminoethyl)carbamate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate→(2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate→PASI-017→PASI-018→PASI-019→PASI-020→PASI-021→PASI-022→#N/A
Intermediates available on this site
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