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CAS 1885-14-9
phenyl carbonochloridateCarbonochloridic acid phenyl ester
Codes: LENT-011, POSA-018, (XIV)859946-1-a
Application context (from source-drug indications)
Renal cell carcinomaLenvatinib MesilateEndometrial cancerLenvatinib MesilateHepatocellular carcinomaLenvatinib MesilateThyroid cancerLenvatinib MesilateCandidiasisPosaconazoleAspergillus infectionPosaconazoleFungal infectionPosaconazoleOral candidiasisPosaconazoleCoccidioidomycosisPosaconazoleHistoplasmosisPosaconazoleBiliary tract cancerTasurgratinibBile duct cancerTasurgratinibSolid tumourTasurgratinibCholangiocarcinomaTasurgratinibBreast cancerTasurgratinibHepatic function declineTasurgratinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lenvatinib Mesilate | Tier A — Act now | 2028 |
| Posaconazole | Tier C — Watch / trade | - |
| Tasurgratinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-2-chlorobenzonitrile→4-amino-2-methoxybenzonitrile→5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione→4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid→4-chloro-7-methoxyquinoline-6-carbonyl chloride→4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide→phenyl carbonochloridate→phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→cyclopropanamine
(R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propane-1,2-diol→(R)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl methanesulfonate→(R)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole→diethyl malonate→ethyl (5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-2-oxotetrahydrofuran-3-carboxylate→(R)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)-5-(1H-1,2,4-triazol-1-yl)pentane-1,4-diol→(R)-2-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)propane-1,3-diyl bis(4-methylbenzenesulfonate)→((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate→4-(4-(4-nitrophenyl)piperazin-1-yl)phenol→1-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-4-(4-nitrophenyl)piperazine→4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)aniline→phenyl carbonochloridate→phenyl (4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)carbamate→N-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)hydrazinecarboxamide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one→(2S,3R)-2-((benzyloxy)methoxy)pentan-3-yl 4-bromobenzenesulfonate→2-chloro-1-(2,4-difluorophenyl)ethan-1-one→2-(2,4-difluorophenyl)-2-oxoethyl acetate→2-(2,4-difluorophenyl)allyl acetate→2-(2,4-difluorophenyl)prop-2-en-1-ol→(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol→1H-1,2,4-triazole
4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)aniline→phenyl carbonochloridate→phenyl (4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)carbamate→ethyl (S)-2-hydroxypropanoate→pyrrolidine→(S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one→(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one→(S)-2-(benzyloxy)pentan-3-one→(2S)-2-(benzyloxy)pentan-3-ol→1-chloro-4-(methylsulfonyl)benzene→(2S)-2-(benzyloxy)pentan-3-yl 4-chlorobenzenesulfonate→((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazine (2R,3R)-2,3-bis(benzoyloxy)succinate→N'-((2S,3S)-2-(benzyloxy)pentan-3-yl)formohydrazide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one→POSA-034→4-(4-(4-aminophenyl)piperazin-1-yl)phenol
((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate→4-(4-(4-nitrophenyl)piperazin-1-yl)phenol→4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)aniline→phenyl carbonochloridate→phenyl (4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)carbamate→N'-((2S,3S)-2-(benzyloxy)pentan-3-yl)formohydrazide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one→4-(4-(4-aminophenyl)piperazin-1-yl)phenol→4-methoxyaniline→N,N-bis(2-chloroethyl)-4-nitroaniline→1-(4-methoxyphenyl)-4-(4-nitrophenyl)piperazine
(S,E)-N'-(2-(benzyloxy)propylidene)formohydrazide→((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate→phenyl carbonochloridate→N'-((2S,3S)-2-(benzyloxy)pentan-3-yl)formohydrazide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one→2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-bromophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one→phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate→2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one→methyl 2-hydroxypropanoate→(chloromethyl)benzene→methyl 2-(benzyloxy)propanoate→(S)-1-phenylethan-1-amine→(S)-1-phenylethan-1-amine (S)-2-(benzyloxy)propanoate→methyl (S)-2-(benzyloxy)propanoate→(S)-2-(benzyloxy)propanal→formohydrazide
3,4-Dihydroxybenzaldehyde→1-Bromo-2-methoxyethane→3-Hydroxy-4-(2-methoxyethoxy)benzaldehyde→3-(Benzyloxy)-4-(2-methoxyethoxy)benzaldehyde→Nitrocarbol→2-(Benzyloxy)-1-(2-methoxyethoxy)-4-[(E)-2-nitroethenyl]benzene→6-(2-Methoxyethoxy)-1H-indol-5-ol→N-(4-Chloropyridin-2-yl)acetamide→2-Amino-4-chloropyridine→N-(4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-yl)acetamide→4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-amine→Phenyl methylcarbamate→Aminomethane hydrochloride→Carbonochloridic acid phenyl ester→1,4-Dioxane-2,5-diol→5-[(2-Aminopyridin-4-yl)oxy]-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide→4-[1-(tert-Butoxycarbonyl)piperidin-4-yl]benzoic acid→6-(2-Methoxyethoxy)-N-methyl-5-([2-[4-(piperidin-4-yl)benzamido]pyridin-4-yl]oxy)-1H-indole-1-carboxamide→2-Oxidanylethanal
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 4-Chloro-7-methoxyquinoline -6-carboxylic acid methyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-Chloro-7-methoxyquinoline -6-carboxamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-(2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl-urea Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Amino-3-chlorophenol Pharmaceutical Intermediates | On request | On request | On request | — |
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