CAS 1885123-22-7

2-chloro-6-fluoroquinoline-4-carbonyl chloride

Codes: M-5717-008

Application context (from source-drug indications)

Plasmodium infectionCabamiquine

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Cabamiquine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

CabamiquineOptimised routesteps: 6total yield: 0.6 g

6-fluoro-2-hydroxyquinoline-4-carboxylic acid→2-chloro-6-fluoroquinoline-4-carbonyl chloride→2-chloro-6-fluoro-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide→4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine→1-bromo-4-(bromomethyl)benzene→4-(4-bromobenzyl)morpholine

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