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CAS 197512-40-6
1-(4-Chlorophenyl)-1-(pyridin-2-yl)ethanol
Codes: Chlorphenamine Maleate-001
Application context (from source-drug indications)
Nasal congestionDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideSneezingDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideCoughDextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideCommon coldAcetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/CaffeineHypersensitivity reactionChlorphenamine MaleateSeasonal allergic rhinitisChlorphenamine MaleateDermatitisChlorphenamine MaleateUrticariaChlorphenamine MaleatePruritusChlorphenamine MaleateDrug eruptionChlorphenamine Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chloride | Tier C — Watch / trade | - |
| Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine | Tier C — Watch / trade | - |
| Chlorphenamine Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideOptimised routesteps: 4total yield: /
1-(4-Chlorophenyl)-1-(pyridin-2-yl)ethanol→2-[1-(4-Chlorophenyl)vinyl]pyridine→N-Cyano-4-methyl-N-phenylbenzenesulfonamide→(2Z)-3-(4-Chlorophenyl)-3-(pyridin-2-yl)acrylonitrile→3-(4-chlorophenyl)-3-(pyridin-2-yl)propanenitrile→N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]amine
Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/CaffeineOptimised routesteps: 4total yield: /
1-(4-Chlorophenyl)-1-(pyridin-2-yl)ethanol→2-[1-(4-Chlorophenyl)vinyl]pyridine→N-Cyano-4-methyl-N-phenylbenzenesulfonamide→(2Z)-3-(4-Chlorophenyl)-3-(pyridin-2-yl)acrylonitrile→3-(4-chlorophenyl)-3-(pyridin-2-yl)propanenitrile→N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]amine
1-(4-Chlorophenyl)-1-(pyridin-2-yl)ethanol→2-[1-(4-Chlorophenyl)vinyl]pyridine→N-Cyano-4-methyl-N-phenylbenzenesulfonamide→(2Z)-3-(4-Chlorophenyl)-3-(pyridin-2-yl)acrylonitrile→3-(4-chlorophenyl)-3-(pyridin-2-yl)propanenitrile→N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]amine
Intermediates available on this site
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