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CAS 19790-60-4
3-(benzyloxy)propanal3-Benzyloxy-1-propanal
Codes: ATOR-050, Atorvastatin-113
Application context (from source-drug indications)
Type 2 diabetesAtorvastatin Calcium Hydrate/Metformin HydrochlorideHyperlipidaemiaAtorvastatin Calcium Hydrate/Metformin HydrochlorideCardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypercholesterolaemiaAtorvastatin Calcium Hydrate/RamiprilHypertensionAtorvastatin Calcium Hydrate/RamiprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontiumHyperlipoproteinaemia type IIIAtorvastatin Calcium HydrateHyperlipidaemiaAtorvastatin Calcium HydrateHeterozygous familial hypercholesterolaemiaAtorvastatin Calcium HydrateHeart failureAtorvastatin Calcium HydrateType 2 diabetesAtorvastatin Calcium HydrateStrokeAtorvastatin Calcium Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin Calcium Hydrate/Metformin Hydrochloride | Tier C — Watch / trade | - |
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin Calcium Hydrate/Irbesartan | Tier C — Watch / trade | - |
| Atorvastatin Calcium Hydrate/Ramipril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
| Atorvastatin Calcium Hydrate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide→tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→(3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate→3-(benzyloxy)propanal→ATOR-051→1,2-bis((2R,5R)-2,5-dimethylphospholan-1-yl)ethane→lithium 2,2,5,7,8-pentamethylchroman-6-olate→ATOR-054→ATOR-055→lithium 1-(tert-butoxy)ethenolate→(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate→tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
(4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→Acetic acid chloride→(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→3-Benzyloxy-1-propanal→(3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid→(4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R)-5-(Benzyloxy)-3-hydroxypentanoic acid→Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate→Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate→(4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid→Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide→tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→(3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate→3-(benzyloxy)propanal→ATOR-051→1,2-bis((2R,5R)-2,5-dimethylphospholan-1-yl)ethane→lithium 2,2,5,7,8-pentamethylchroman-6-olate→ATOR-054→ATOR-055→lithium 1-(tert-butoxy)ethenolate→(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate→tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide→tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→(3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate→3-(benzyloxy)propanal→ATOR-051→1,2-bis((2R,5R)-2,5-dimethylphospholan-1-yl)ethane→lithium 2,2,5,7,8-pentamethylchroman-6-olate→ATOR-054→ATOR-055→lithium 1-(tert-butoxy)ethenolate→(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate→tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
(4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→Acetic acid chloride→(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→3-Benzyloxy-1-propanal→(3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid→(4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R)-5-(Benzyloxy)-3-hydroxypentanoic acid→Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate→Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate→(4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid→Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide→tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→(3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate→3-(benzyloxy)propanal→ATOR-051→1,2-bis((2R,5R)-2,5-dimethylphospholan-1-yl)ethane→lithium 2,2,5,7,8-pentamethylchroman-6-olate→ATOR-054→ATOR-055→lithium 1-(tert-butoxy)ethenolate→(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate→tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate→tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
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