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CAS 19810-31-2
2-(Benzyloxy)acetyl chlorideBenzyloxyacetyl chloride
Codes: (II)101438-5-a, (II)101438-61-a, Enalapril-037, (II)140605-32-a
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateCardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilBladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Essential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril MaleatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelNon-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Enalapril Maleate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,2R)-2-phenylcyclohexan-1-ol→2-(Benzyloxy)acetyl chloride→(1S,2R)-2-phenylcyclohexyl 2-(benzyloxy)acetate→(1S,2R)-2-phenylcyclohexyl 2-hydroxyacetate→(3R,4S)-3-hydroxy-4-phenylazetidin-2-one→(1S,2R)-2-phenylcyclohexyl 2-[(triisopropylsilyl)oxy]acetate→1,1,1-Trimethyl-N-[(E)-phenylmethylidene]silanamine→Benzaldehyde→(3R,4S)-4-Phenyl-3-{[tris(propan-2-yl)silyl]oxy}azetidin-2-one→(3R,4S)-3-(1-Ethoxyethoxy)-4-phenylazetidin-2-one→alpha-Chlorobenzaldehyde→1-Benzoyl-3(R)-(1-ethoxyethoxy)-4(S)-phenylazetidin-2-one→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-[[(2R,3S)-3-(benzoylamino)-2-(1-ethoxyethoxy)-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-7-[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate
2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine→2-(Benzyloxy)acetyl chloride→2-(Benzyloxy)-1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)ethan-1-one→N-[(1Z)-Phenylmethylidene]benzamide→N-[(1S,2R)-2-(Benzyloxy)-3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)-3-oxo-1-phenylpropyl]benzamide
2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde→L-Alanine methyl ester→Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate→Benzyloxyacetyl chloride→Triphenyl(phenylmethyl)phosphonium chloride→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate→Benzylidene(triphenyl)-lambda5-phosphane→Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate→(2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid→Benzyl L-prolinate→Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate→Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate→Ethyl alcohol→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine→2-(Benzyloxy)acetyl chloride→2-(Benzyloxy)-1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)ethan-1-one→N-[(Z)-Phenylmethylidene]carbamic acid tert-butyl ester→tert-Butyl [(1S,2R)-2-(benzyloxy)-3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)-3-oxo-1-phenylpropyl]carbamate
2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde→L-Alanine methyl ester→Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate→Benzyloxyacetyl chloride→Triphenyl(phenylmethyl)phosphonium chloride→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate→Benzylidene(triphenyl)-lambda5-phosphane→Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate→(2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid→Benzyl L-prolinate→Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate→Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate→Ethyl alcohol→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde→L-Alanine methyl ester→Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate→Benzyloxyacetyl chloride→Triphenyl(phenylmethyl)phosphonium chloride→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate→Benzylidene(triphenyl)-lambda5-phosphane→Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate→(2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid→Benzyl L-prolinate→Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate→Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate→Ethyl alcohol→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
(1S,2R)-2-phenylcyclohexan-1-ol→2-(Benzyloxy)acetyl chloride→(1S,2R)-2-phenylcyclohexyl 2-(benzyloxy)acetate→(1S,2R)-2-phenylcyclohexyl 2-hydroxyacetate→(3R,4S)-3-hydroxy-4-phenylazetidin-2-one→(1S,2R)-2-phenylcyclohexyl 2-[(triisopropylsilyl)oxy]acetate→1,1,1-Trimethyl-N-[(E)-phenylmethylidene]silanamine→Benzaldehyde→(3R,4S)-4-Phenyl-3-{[tris(propan-2-yl)silyl]oxy}azetidin-2-one→(3R,4S)-3-(1-Ethoxyethoxy)-4-phenylazetidin-2-one→alpha-Chlorobenzaldehyde→1-Benzoyl-3(R)-(1-ethoxyethoxy)-4(S)-phenylazetidin-2-one→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-[[(2R,3S)-3-(benzoylamino)-2-(1-ethoxyethoxy)-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-7-[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate
2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine→2-(Benzyloxy)acetyl chloride→2-(Benzyloxy)-1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)ethan-1-one→N-[(1Z)-Phenylmethylidene]benzamide→N-[(1S,2R)-2-(Benzyloxy)-3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)-3-oxo-1-phenylpropyl]benzamide
2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine→2-(Benzyloxy)acetyl chloride→2-(Benzyloxy)-1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)ethan-1-one→N-[(Z)-Phenylmethylidene]carbamic acid tert-butyl ester→tert-Butyl [(1S,2R)-2-(benzyloxy)-3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)-3-oxo-1-phenylpropyl]carbamate
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