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CAS 198480-21-6
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole
Codes: BAZE-009
Application context (from source-drug indications)
Oestrogen deficiency syndromeConjugated Estrogens/Bazedoxifene AcetateOsteoporosisConjugated Estrogens/Bazedoxifene AcetateVasomotor symptomsConjugated Estrogens/Bazedoxifene AcetateNon-invasive ductal carcinomaConjugated Estrogens/Bazedoxifene AcetateAnxietyConjugated Estrogens/Bazedoxifene AcetateMenopausal symptomsConjugated Estrogens/Bazedoxifene AcetatePostmenopausal osteoporosisBazedoxifene AcetateBreast cancerBazedoxifene AcetateOsteoporosisBazedoxifene AcetateMenopausal symptomsBazedoxifene Acetate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Conjugated Estrogens/Bazedoxifene Acetate | Tier C — Watch / trade | - |
| Bazedoxifene Acetate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(benzyloxy)aniline hydrochloride→1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→ethyl 2-(4-(chloromethyl)phenoxy)acetate→ethyl 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetate→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol→5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-1-(4-(2-bromoethoxy)benzyl)-3-methyl-1H-indole→azepane→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→1-(2-chloroethyl)azepane hydrochloride→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→(4-(2-(azepan-1-yl)ethoxy)phenyl)methanol→1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→azepane→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-(hydroxymethyl)phenol→2-chloroacetonitrile→2-(4-(hydroxymethyl)phenoxy)acetonitrile→2-(4-(chloromethyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetic acid→1-(azepan-1-yl)-2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→azepane→1,2-dibromoethane→1-(2-bromoethyl)azepane→4-(benzyloxy)aniline→N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(2-(4-((1-(4-(benzyloxy)phenyl)hydrazinyl)methyl)phenoxy)ethyl)azepane→1-(benzyloxy)-4-(prop-1-yn-1-yl)benzene
4-(benzyloxy)aniline hydrochloride→1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→ethyl 2-(4-(chloromethyl)phenoxy)acetate→ethyl 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetate→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol→5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-1-(4-(2-bromoethoxy)benzyl)-3-methyl-1H-indole→azepane→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→1-(2-chloroethyl)azepane hydrochloride→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→(4-(2-(azepan-1-yl)ethoxy)phenyl)methanol→1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride
5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→azepane→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-(hydroxymethyl)phenol→2-chloroacetonitrile→2-(4-(hydroxymethyl)phenoxy)acetonitrile→2-(4-(chloromethyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetonitrile→2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetic acid→1-(azepan-1-yl)-2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→azepane→1,2-dibromoethane→1-(2-bromoethyl)azepane→4-(benzyloxy)aniline→N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→1-(2-(4-((1-(4-(benzyloxy)phenyl)hydrazinyl)methyl)phenoxy)ethyl)azepane→1-(benzyloxy)-4-(prop-1-yn-1-yl)benzene
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