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CAS 20283-95-8
(4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one
Codes: DUTA-022
Application context (from source-drug indications)
Benign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideUrinary retentionDutasterideBenign prostatic hyperplasiaDutasterideAlopeciaDutasterideAlcohol abuseDutasterideBladder cancerDutasterideProstate cancerDutasteride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one→3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid→3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic (ethyl carbonic) anhydride→(4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-11a-hydroxy-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-acetyl-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid→(ethyl carbonic) (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic anhydride→2,5-bis(trifluoromethyl)aniline→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→(3R,4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-3-iodo-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one→3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid→3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic (ethyl carbonic) anhydride→(4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-11a-hydroxy-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-acetyl-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid→(ethyl carbonic) (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic anhydride→2,5-bis(trifluoromethyl)aniline→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→(3R,4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-3-iodo-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
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