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CAS 2032-35-1

2-bromo-1,1-diethoxyethane2-Bromo-1,1-diethoxyethane

Codes: LAMI-008, (I)158395-3-a

Application context (from source-drug indications)

HIV infectionDolutegravir/Lamivudine/Tenofovir AlafenamideHIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateHepatitis BLamivudineChronic hepatitis BLamivudineHIV infectionLamivudineRett syndromeLamivudineAlzheimer's diseaseLamivudineRetinal detachmentLamivudineVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionAmlodipine Camsylate

Source drugs (routes using this intermediate)

DrugTierExpiry
Dolutegravir/Lamivudine/Tenofovir AlafenamideTier C — Watch / trade-
Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
Olmesartan Medoxomil/Amlodipine orotateTier C — Watch / trade-
Valsartan/Amlodipine OrotateTier C — Watch / trade-
LamivudineTier C — Watch / trade-
Amlodipine OrotateTier C — Watch / trade-
Amlodipine CamsylateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Dolutegravir/Lamivudine/Tenofovir AlafenamideOriginator routesteps: 6total yield: 165 mg
2,3-dihydroxypropyl benzoate→2-oxoethyl benzoate→2,2-diethoxyethanethiol→(5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate→4-aminopyrimidin-2(1H)-one→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→benzothioic O-acid→2-bromo-1,1-diethoxyethane→S-(2,2-diethoxyethyl) benzothioate
Lamivudine/Tenofovir Disoproxil FumarateOriginator routesteps: 6total yield: 165 mg
2,3-dihydroxypropyl benzoate→2-oxoethyl benzoate→2,2-diethoxyethanethiol→(5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate→4-aminopyrimidin-2(1H)-one→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→benzothioic O-acid→2-bromo-1,1-diethoxyethane→S-(2,2-diethoxyethyl) benzothioate
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOriginator routesteps: 6total yield: 165 mg
2,3-dihydroxypropyl benzoate→2-oxoethyl benzoate→2,2-diethoxyethanethiol→(5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate→4-aminopyrimidin-2(1H)-one→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→benzothioic O-acid→2-bromo-1,1-diethoxyethane→S-(2,2-diethoxyethyl) benzothioate
Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 2total yield: /
2-Bromo-1,1-diethoxyethane→2,2-Diethoxyethyl acetate→2,2-Diethoxyethanol
Valsartan/Amlodipine OrotateOptimised routesteps: 2total yield: /
2-Bromo-1,1-diethoxyethane→2,2-Diethoxyethyl acetate→2,2-Diethoxyethanol
LamivudineOriginator routesteps: 6total yield: 165 mg
2,3-dihydroxypropyl benzoate→2-oxoethyl benzoate→2,2-diethoxyethanethiol→(5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate→4-aminopyrimidin-2(1H)-one→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→benzothioic O-acid→2-bromo-1,1-diethoxyethane→S-(2,2-diethoxyethyl) benzothioate
Amlodipine OrotateOptimised routesteps: 2total yield: /
2-Bromo-1,1-diethoxyethane→2,2-Diethoxyethyl acetate→2,2-Diethoxyethanol
Amlodipine CamsylateOptimised routesteps: 2total yield: /
2-Bromo-1,1-diethoxyethane→2,2-Diethoxyethyl acetate→2,2-Diethoxyethanol

Intermediates available on this site

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