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CAS 2035468-75-6
(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
Codes: Tenofovir disoproxil phosphate-047
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 3total yield: /
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
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