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CAS 206184-49-8,147127-20-6,147127-19-3
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid
Codes: Tenofovir disoproxil phosphate-049
Application context (from source-drug indications)
HIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis BTenofovir disoproxil phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Tenofovir disoproxil phosphateOptimised routesteps: 1total yield: 112.26g(Tenofovir disoproxil phosphate-051)
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
Intermediates available on this site
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