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CAS 2062661-50-9
tert-butyl (3S,4S)-3-methyl-4-(8-oxo-3-(tetrahydro-2H-pyran-4-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)pyrrolidine-1-carboxylate
Codes: IMR-687-015
Application context (from source-drug indications)
Systolic heart failureTovinontrineDiastolic heart failureTovinontrineHeart diseaseTovinontrineHeart failureTovinontrineSickle cell diseaseTovinontrineBeta thalassaemiaTovinontrine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tovinontrine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine→ethyl (E)-but-2-enoate→ethyl 1-benzyl-4-methylpyrrolidine-3-carboxylate→ethyl (3S,4S)-1-benzyl-4-methylpyrrolidine-3-carboxylate→1-(tert-butyl) 3-ethyl (3S,4S)-4-methylpyrrolidine-1,3-dicarboxylate→(3S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidine-3-carboxylic acid→tert-butyl (3S,4S)-3-(methoxy(methyl)carbamoyl)-4-methylpyrrolidine-1-carboxylate→tert-butyl (3S,4S)-3-acetyl-4-methylpyrrolidine-1-carboxylate→tert-butyl (3S,4S)-3-(2-bromoacetyl)-4-methylpyrrolidine-1-carboxylate→methyl 2,4-dibromo-1H-imidazole-5-carboxylate→methyl 2,4-dibromo-1-(2-((3S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-3-yl)-2-oxoethyl)-1H-imidazole-5-carboxylate→ert-butyl (3S,4S)-3-(1,3-dibromo-8-oxo-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-4-methylpyrrolidine-1-carboxylate→2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→tert-butyl (3S,4S)-3-(1-bromo-3-(3,6-dihydro-2H-pyran-4-yl)-8-oxo-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-4-methylpyrrolidine-1-carboxylate→tert-butyl (3S,4S)-3-methyl-4-(8-oxo-3-(tetrahydro-2H-pyran-4-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)pyrrolidine-1-carboxylate→6-((3S,4S)-4-methylpyrrolidin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5-a]pyrazin-8(7H)-one hydrochloride→2-(chloromethyl)pyrimidine→1H-imidazole-5-carboxylic acid→methyl 1H-imidazole-5-carboxylate
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