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CAS 2097334-20-6
(S)-3-((tert-butoxycarbonyl)amino)-2-(4-(((2,4-dimethylbenzoyl)oxy)methyl)phenyl)propanoic acid
Codes: NETA-023
Application context (from source-drug indications)
Ocular hypertensionNetarsudil DimesylateOpen-angle glaucomaNetarsudil DimesylateFuchs endothelial corneal dystrophyNetarsudil DimesylateCorneal oedemaNetarsudil DimesylateGlaucomaNetarsudil Dimesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Netarsudil Dimesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 2-[4-(hydroxymethyl)phenyl]acetate→2-((2-carboxy-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)ethyl)carbamoyl)benzoic acid→(S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate→methyl 2-(4-(hydroxymethyl)phenyl)acetate→2,4-dimethylbenzoic acid→4-(2-methoxy-2-oxoethyl)benzyl 2,4-dimethylbenzoate→(R)-5-benzyloxazolidin-2-one→(R)-4-(2-(5-benzyl-2-oxooxazolidin-3-yl)-2-oxoethyl)benzyl 2,4-dimethylbenzoate→tert-butyl ((1H-benzo[d][1,2,3]triazol-1-yl)methyl)carbamate→4-((S)-1-((R)-5-benzyl-2-oxooxazolidin-3-yl)-3-((tert-butoxycarbonyl)amino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate→(S)-3-((tert-butoxycarbonyl)amino)-2-(4-(((2,4-dimethylbenzoyl)oxy)methyl)phenyl)propanoic acid→1,1,1-trichloro-2-methylpropan-2-yl carbonochloridate
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