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CAS 21149-38-2
2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide
Codes: DUTA-007
Application context (from source-drug indications)
Benign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideUrinary retentionDutasterideBenign prostatic hyperplasiaDutasterideAlopeciaDutasterideAlcohol abuseDutasterideBladder cancerDutasterideProstate cancerDutasteride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid→2,5-bis(trifluoromethyl)aniline→(8S,9S,10R,13S,14S,17S)-N-(2,5-bis(trifluoromethyl)phenyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide→3-((3S,3aS,5aS,6R,9aS,9bS)-3-((2,5-bis(trifluoromethyl)phenyl)carbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid→(4aR,4bS,6aS,7S,9aS,9bS)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide
(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid→2,5-bis(trifluoromethyl)aniline→(8S,9S,10R,13S,14S,17S)-N-(2,5-bis(trifluoromethyl)phenyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide→3-((3S,3aS,5aS,6R,9aS,9bS)-3-((2,5-bis(trifluoromethyl)phenyl)carbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid→(4aR,4bS,6aS,7S,9aS,9bS)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide→2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide
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