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CAS 212650-43-6
4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid4-[(tert-Butoxy)carbonyl]morpholine-3-carboxylic acid
Codes: Elinzanetant-001, (XIII)448314-1-b
Application context (from source-drug indications)
Hot flushesElinzanetantVasomotor symptomsElinzanetantHR阳性乳腺癌Elinzanetant睡眠障碍ElinzanetantMenopausal symptomsElinzanetantOpioid dependenceElinzanetant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Elinzanetant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid→tert-butyl 3-(((R)-3-hydroxy-1-methoxy-1-oxopropan-2-yl)carbamoyl)morpholine-4-carboxylate→(7R)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,9-dione→((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol→(7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-((7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→tert-butyl (6-chloro-4-methylpyridin-3-yl)(methyl)carbamate→6-chloro-N,4-dimethylpyridin-3-amine→(4-fluoro-2-methylphenyl)boronic acid→6-chloro-4-(4-fluoro-2-methylphenyl)-N-methylpyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride
(7S,9aS)-7-([[tert-Butyl(dimethyl)silyl]oxy]methyl)octahydropyrazino[2,1-c][1,4]oxazine→4-[(tert-Butoxy)carbonyl]morpholine-3-carboxylic acid→(R)-Methyl 2-amino-3-hydroxypropanoate hydrochloride→(3R)-4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid→tert-Butyl 3-[[(2R)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]carbamoyl]morpholine-4-carboxylate→(7R)-7-(Hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,9-dione→[(7S)-Octahydropyrazino[2,1-c][1,4]oxazin-7-yl]methanol→N-Benzyl-D-serine methyl ester→tert-Butyl (3R)-3-[benzyl[(2R)-3-hydroxy-1-methoxy-1-oxopropan-2-yl]carbamoyl]morpholine-4-carboxylate→(7R,9aR)-8-Benzyl-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,9-dione→[(7S,9aS)-8-Benzyloctahydropyrazino[2,1-c][1,4]oxazin-7-yl]methanol→(7S,9aS)-8-Benzyl-7-([[tert-butyl(dimethyl)silyl]oxy]methyl)octahydropyrazino[2,1-c][1,4]oxazine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-Boc-3-morpholinecarboxylic Acid Pharmaceutical Intermediates | On request | On request | On request | — |
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