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CAS 214403-86-8

(1H-imidazol-1-yl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride

Codes: DIQU-004

Application context (from source-drug indications)

Dry eye diseaseDiquafosol TetrasodiumDry eye syndromeDiquafosol TetrasodiumKeratoconjunctivitis siccaDiquafosol Tetrasodium

Source drugs (routes using this intermediate)

DrugTierExpiry
Diquafosol TetrasodiumTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Diquafosol TetrasodiumOptimised routesteps: 2total yield: /
((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate→1H-imidazole→(1H-imidazol-1-yl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride

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