CAS 218301-22-5

2-fluoro-5-formylbenzonitrile

Codes: OLAP-004, ENTR-002

Application context (from source-drug indications)

Endometrial cancerOlaparibCastration-resistant prostate cancerOlaparibProstate cancerOlaparibPeritoneal cancerOlaparibEpithelial ovarian cancerOlaparibFallopian tube cancerOlaparibSolid tumourEntrectinibNon-small cell lung cancerEntrectinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Olaparib	Tier A — Act now	2028
Entrectinib	Tier C — Watch / trade	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

OlaparibOriginator routesteps: 6total yield: 1.27 kg

3-hydroxyisobenzofuran-1(3H)-one→dimethyl phosphonate→dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carboxylate→4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one→cyclopropanecarbonyl chloride

OlaparibOptimised routesteps: 6total yield: 8.67 g

3-hydroxyisobenzofuran-1(3H)-one→2-fluoro-5-formylbenzonitrile→(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid→cyclopropanecarbonyl chloride→2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile→cyclopropyl(piperazin-1-yl)methanone hydrochloride→piperazine

EntrectinibOriginator routesteps: 11total yield: 1.61 g

1-bromo-3,5-difluorobenzene→2-fluoro-5-formylbenzonitrile→5-((3,5-difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile→5-(3,5-difluorobenzoyl)-2-fluorobenzonitrile→(3-amino-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→(3-amino-1-trityl-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→4-(4-methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→2-amino-N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide→tetrahydro-4H-pyran-4-one

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	2-Fluoro-5-formylbenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.