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CAS 220593-79-3
8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
Codes: TNP-2092-008
Application context (from source-drug indications)
假体相关感染Rifaquizinone糖尿病足溃疡RifaquizinoneInfectious skin diseaseRifaquizinoneSkin and skin structure infectionRifaquizinoneBacterial skin diseaseRifaquizinoneHelicobacter pylori infectionRifaquizinone
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Rifaquizinone | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-1-benzylpyrrolidin-3-ol→(S)-1-benzylpyrrolidin-3-yl methanesulfonate→(R)-1-benzylpyrrolidine-3-carbonitrile→(R)-1-(1-benzylpyrrolidin-3-yl)cyclopropan-1-amine→tert-butyl 4-oxopiperidine-1-carboxylate→tert-butyl (R)-4-((1-(1-benzylpyrrolidin-3-yl)cyclopropyl)(methyl)amino)piperidine-1-carboxylate→tert-butyl (R)-4-(methyl(1-(pyrrolidin-3-yl)cyclopropyl)amino)piperidine-1-carboxylate→8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid→ethyl (R)-8-(3-(1-((1-(tert-butoxycarbonyl)piperidin-4-yl)(methyl)amino)cyclopropyl)pyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylate→(R)-8-(3-(1-((1-(tert-butoxycarbonyl)piperidin-4-yl)(methyl)amino)cyclopropyl)pyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid→(R)-1-cyclopropyl-7-fluoro-9-methyl-8-(3-(1-(methyl(piperidin-4-yl)amino)cyclopropyl)pyrrolidin-1-yl)-4-oxo-4H-quinolizine-3-carboxylic acid→TNP-2092-012
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