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CAS 2224-77-3
3-(4-Chlorophenyl)-2,3-dihydro-1H-isoindol-1-one
Codes: Chlorthalidone-010
Application context (from source-drug indications)
HypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneEssential hypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneHypertensionChlorthalidoneOedemaChlorthalidoneDiabetes insipidusChlorthalidoneKidney stonesChlorthalidoneHypercalciuriaChlorthalidoneType 1 diabetesChlorthalidone
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Azilsartan Medoxomil Potassium/Chlorthalidone | Tier C — Watch / trade | - |
| Chlorthalidone | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Azilsartan Medoxomil Potassium/ChlorthalidoneOptimised routesteps: 6total yield: 198g(Chlorthalidone (Free))
1-Chlorobenzene→1,2-Benzenedicarboxylic acid anhydride→2-(4-Chlorobenzoyl)benzoic acid→Sodium 2-(4-chlorobenzoyl)benzoate→4-(4-Chlorophenyl)-1H-2,3-benzoxazin-1-one→3-(4-Chlorophenyl)-2,3-dihydro-1H-isoindol-1-one→Chloridosulfuric acid→2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonyl chloride→2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
1-Chlorobenzene→1,2-Benzenedicarboxylic acid anhydride→2-(4-Chlorobenzoyl)benzoic acid→Sodium 2-(4-chlorobenzoyl)benzoate→4-(4-Chlorophenyl)-1H-2,3-benzoxazin-1-one→3-(4-Chlorophenyl)-2,3-dihydro-1H-isoindol-1-one→Chloridosulfuric acid→2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonyl chloride→2-Chloro-5-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
Intermediates available on this site
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