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CAS 2227376-67-0
Di-tert-butyl (3R,4S,3'R,4'S)-3,3'-(pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(2-oxo-4-phenylazetidine-1-carboxylate)
Codes: (V)140605-34-a
Application context (from source-drug indications)
Bladder cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck cancerDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Head and neck squamous cell carcinomaDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Solid tumourDocetaxel polymeric micelle (Samyang Biopharmaceuticals)Non-small cell lung cancerDocetaxel （Beihai）Prostate cancerDocetaxel （Beihai）Castration-resistant prostate cancerDocetaxel （Beihai）Breast cancerDocetaxel （Beihai）Head and neck cancerDocetaxel （Beihai）Head and neck squamous cell carcinomaDocetaxel （Beihai）
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| Docetaxel （Beihai） | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3R,4S)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(Pentane-1,5-diyl)bis[chlorodi(propan-2-yl)silane]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis[1-(4-methoxyphenyl)-4-phenylazetidin-2-one]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(4-phenylazetidin-2-one)→Di-tert-butyl (3R,4S,3'R,4'S)-3,3'-(pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(2-oxo-4-phenylazetidine-1-carboxylate)
(3R,4S)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one→(Pentane-1,5-diyl)bis[chlorodi(propan-2-yl)silane]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis[1-(4-methoxyphenyl)-4-phenylazetidin-2-one]→(3R,4S,3'R,4'S)-3,3'-(Pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(4-phenylazetidin-2-one)→Di-tert-butyl (3R,4S,3'R,4'S)-3,3'-(pentane-1,5-diylbis[[di(propan-2-yl)silanediyl]oxy])bis(2-oxo-4-phenylazetidine-1-carboxylate)
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