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CAS 2239278-06-7
3-(2-amino-6-((triisopropylsilyl)ethynyl)pyrimidin-4-yl)-2-methylbenzonitrile
Codes: AB-928-005
Application context (from source-drug indications)
胰腺导管癌EtrumadenantUrothelial carcinomaEtrumadenantMetastatic cancerEtrumadenantNon-small cell lung cancerEtrumadenantLung cancerEtrumadenantRectal cancerEtrumadenant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Etrumadenant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloropyrimidin-2-amine→2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile→3-(2-amino-6-chloropyrimidin-4-yl)-2-methylbenzonitrile→ethynyltriisopropylsilane→3-(2-amino-6-((triisopropylsilyl)ethynyl)pyrimidin-4-yl)-2-methylbenzonitrile→3-(2-amino-6-ethynylpyrimidin-4-yl)-2-methylbenzonitrile→2-(6-(azidomethyl)pyridin-2-yl)propan-2-ol→methyl 6-(hydroxymethyl)picolinate→2-(6-(hydroxymethyl)pyridin-2-yl)propan-2-ol
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