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CAS 22818-40-2
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
Codes: Amoxicillin-018
Application context (from source-drug indications)
Helicobacter pylori infectionAmoxicillin/Omeprazole/RifabutinDyspepsiaAmoxicillin/Omeprazole/RifabutinDuodenal ulcerRabeprazole Sodium/Metronidazole/AmoxicillinImmune thrombocytopenic purpuraRabeprazole Sodium/Metronidazole/AmoxicillinGastric ulcerRabeprazole Sodium/Metronidazole/AmoxicillinGastritisRabeprazole Sodium/Metronidazole/AmoxicillinHelicobacter pylori infectionRabeprazole Sodium/Metronidazole/AmoxicillinMarginal zone B-cell lymphomaClarithromycin/Rabeprazole Sodium/AmoxicillinDuodenal ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinImmune thrombocytopenic purpuraClarithromycin/Rabeprazole Sodium/AmoxicillinGastric ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinGastritisClarithromycin/Rabeprazole Sodium/AmoxicillinHelicobacter pylori infectionClarithromycin/Rabeprazole Sodium/AmoxicillinBacterial infectionAmoxicillin Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Amoxicillin/Omeprazole/Rifabutin | Tier C — Watch / trade | - |
| Rabeprazole Sodium/Metronidazole/Amoxicillin | Tier C — Watch / trade | - |
| Clarithromycin/Rabeprazole Sodium/Amoxicillin | Tier C — Watch / trade | - |
| Amoxicillin Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→1-Methoxybutane-1,3-dione→Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate→Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate→(+)-6-Aminopenicillanic acid
(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid→(2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid→(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
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