CAS 23426-63-3

methyl 2-bromo-2-methylpropanoate

Codes: ENZA-015

Application context (from source-drug indications)

Hormone-sensitive prostate cancerEnzalutamideCastration-resistant prostate cancerEnzalutamideProstate cancerEnzalutamide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Enzalutamide	Tier A — Act now	2027

Position in synthesis routes (up/downstream chain)

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EnzalutamideOptimised routesteps: 2total yield: 152.3 g

4-amino-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile→methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate→methyl 2-bromo-2-methylpropanoate

Intermediates available on this site

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