← Back to patent-cliff list
CAS 2374-03-0
(4-Carboxy-2-hydroxyphenyl)amine4-amino-3-hydroxybenzoic acid
Codes: (I)409139-2-a, (IX)409139-3-a, (V)409139-4-a, (V)409139-5-a, (VIII)409139-6-a, (IId)409139-7-a, TAFA-001, (IIIa)409139-1-a, (I)409139-10-a
Application context (from source-drug indications)
Transthyretin amyloidosisTafamidisHeart diseaseTafamidisAmyloid polyneuropathyTafamidis MeglumineTransthyretin amyloidosisTafamidis MeglumineAmyloidosisTafamidis MeglumineCardiomyopathyTafamidis MeglumineLight-chain (AL) amyloidosisTafamidis MeglumineFamilial amyloid neuropathyTafamidis Meglumine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tafamidis | Tier C — Watch / trade | - |
| Tafamidis Meglumine | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4-Carboxy-2-hydroxyphenyl)amine→Orthoformic acid trimethyl ester→1,3-Benzoxazole-6-carboxylic acid→1,3-Benzoxazole-6-carbonyl chloride→1,3-Benzoxazol-6-yl(morpholin-4-yl)methanone→1,3-Dichloro-5-iodobenzene→[2-(3,5-Dichlorophenyl)-1,3-benzoxazol-6-yl]-morpholinomethanone→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3,5-Dichloro-1-benzenecarbonyl chloride→3,5-Dichloro-N-methyl-N-phenylbenzamide→N-[(3,5-Dichlorophenyl)(methoxy)methylidene]-N-methylbenzeniminium trifluoromethanesulfonate→1,3-Dichloro-5-(trimethoxymethyl)benzene→2-(Hydroxymethyl)-2-phenylpropane-1,3-diol→2-Phenylacetaldehyde→2-Ethyl-2-(hydroxymethyl)propane-1,3-diol→1-(3,5-Dichlorophenyl)-4-phenyl-2,6,7-trioxabicyclo[2.2.2]octane→1-(3,5-Dichlorophenyl)-4-ethyl-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3-Methylbutanal→3,3-Dimethylbutanal→2-(Hydroxymethyl)-2-(propan-2-yl)propane-1,3-diol→2-tert-Butyl-2-(hydroxymethyl)propane-1,3-diol→3,5-Dichlorobenzoic acid→1-(3,5-Dichlorophenyl)-4-(propan-2-yl)-2,6,7-trioxabicyclo[2.2.2]octane→4-tert-Butyl-1-(3,5-dichlorophenyl)-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
1,3-Dichloro-5-(trimethoxymethyl)benzene→(±)-1,2,4-Butanetriol→1-(3,5-Dichlorophenyl)-2,7,8-trioxabicyclo[3.2.1]octane→1,2-Dihydroxyethane→2-(3,5-Dichlorophenyl)-2-methoxy-1,3-dioxolane→cis-Cyclohexane-1,3,5-triol→3-(3,5-Dichlorophenyl)-2,4,10-trioxaadamantane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3,5-Dichlorobenzaldehyde→3,5-Dichlorobenzoic acid→2-Amino-5-methylphenol→1-Amino-2-hydroxy-4-ethylbenzene→2-Amino-5-butylphenol→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)-6-methyl-1,3-benzoxazole→2-(3,5-Dichlorophenyl)-6-ethyl-1,3-benzoxazole→6-Butyl-2-(3,5-dichlorophenyl)-1,3-benzoxazole→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→4-([(1E)-(3,5-Dichlorophenyl)methylene]amino)-3-hydroxybenzoic acid
4-amino-3-hydroxybenzoic acid→benzo[d]oxazole-6-carboxylic acid→benzo[d]oxazol-6-yl(morpholino)methanone→1,3-dichloro-5-iodobenzene→(2-(3,5-dichlorophenyl)benzo[d]oxazol-6-yl)(morpholino)methanone
3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.