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CAS 2375682-63-4
(1S)-2'-Chloro-6-methoxy-N-methyl-3,4-dihydro[1,1'-biphenyl]-1(2H)-amine
Codes: (XI)270899-3-a
Application context (from source-drug indications)
Major depressive disorderEsketamine HydrochlorideSuicidal ideationEsketamine HydrochlorideDepressive disorderEsketamine HydrochlorideAnaesthesiaEsketamine HydrochlorideTreatment-resistant depressionEsketamine HydrochloridePainEsketamine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Esketamine Hydrochloride | Tier B — Position early | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Hydroxycyclohex-2-en-1-one→3-Bromo-2-hydroxycyclohex-2-en-1-one→3-Bromo-2-methoxycyclohex-2-en-1-one→2-Methoxycyclohex-2-en-1-one→(o-Chlorophenyl)boronic acid→2'-Chloro-2-methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one→(3S)-2'-Chloro-2-methoxy-3,4,5,6-tetrahydro[1,1'-biphenyl]-3-ol→2,2,2-Trichloro-N-(oxomethylidene)acetamide→(3S)-2'-Chloro-2-methoxy-3,4,5,6-tetrahydro[1,1'-biphenyl]-3-yl carbamate→(1S)-2'-Chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphenyl→(1S)-2'-Chloro-6-methoxy-N-methyl-3,4-dihydro[1,1'-biphenyl]-1(2H)-amine
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