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CAS 253168-83-1
4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Codes: APER-011
Application context (from source-drug indications)
Plaque psoriasisApremilastBehçet's syndromeApremilastOral ulcerApremilastPsoriasisApremilastPsoriatic arthritisApremilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apremilast | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-ethoxy-4-methoxybenzaldehyde→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine→3-nitrophthalic acid→3-ethoxy-4-methoxybenzonitrile→4-nitroisobenzofuran-1,3-dione→2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione→4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Intermediates available on this site
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