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CAS 256504-39-9
ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate
Codes: RIOC-003
Application context (from source-drug indications)
Pulmonary arterial hypertensionRiociguatPulmonary hypertensionRiociguatChronic thromboembolic pulmonary hypertensionRiociguatThrombosisRiociguatLeft ventricular dysfunctionRiociguatIdiopathic pulmonary arterial hypertensionRiociguat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Riociguat | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2-fluorobenzyl)hydrazine→sodium (Z)-1-cyano-3-ethoxy-3-oxoprop-1-en-2-olate→ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate→(E)-3-(dimethylamino)acrylaldehyde→ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide→(E)-2-(phenyldiazenyl)malononitrile→(E)-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine→2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine→methyl carbonochloridate→methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate
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