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CAS 2757103-50-5
(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1,4,20-trihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]tax-11-en-2-yl benzoate
Codes: (XX)101438-72-c
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1,4,20-trihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]tax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,4-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→Acetic acid chloride
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1,4,20-trihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]tax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,4-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→Acetic acid chloride
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