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CAS 2757103-58-3
(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1-hydroxy-9-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate
Codes: (XVII)101438-72-b
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxel
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2alpha,5beta,7beta,13alpha)-1-Hydroxy-10-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,13alpha)-1-Hydroxy-9-methyl-10-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-1,10-Dihydroxy-9-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→Acetic acid acetic anhydride→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1-hydroxy-9-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,5-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate
(2alpha,5beta,7beta,13alpha)-1-Hydroxy-10-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,13alpha)-1-Hydroxy-9-methyl-10-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-1,10-Dihydroxy-9-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→Acetic acid acetic anhydride→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1-hydroxy-9-oxo-5,7,13-tris[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,5-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate
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