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CAS 284030-58-6
methyl 4-amino-2,3-difluoro-5-nitrobenzoate
Codes: SELT-004, BINI-004
Application context (from source-drug indications)
Plexiform neurofibromaSelumetinib sulfateNeurofibromatosis type ISelumetinib sulfateNon-small cell lung cancerBinimetinibMelanomaBinimetinibColorectal cancerBinimetinibHairy cell leukaemiaBinimetinibPlexiform neurofibromaBinimetinibNeurofibromatosis type IBinimetinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Selumetinib sulfate | Tier C — Watch / trade | 2032 |
| Binimetinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→aniline→SELT-006→SELT-007→SELT-008→SELT-009→SELT-010→SELT-011→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→SELT-013
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→2-fluoroaniline→methyl 4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-nitrobenzoate→methyl 4-fluoro-5-((2-fluorophenyl)amino)-1H-benzo[d]imidazole-6-carboxylate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1H-benzo[d]imidazole-6-carboxylate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→methyl 2,4-diamino-3-fluoro-5-nitrobenzoate→methyl 2,4,5-triamino-3-fluorobenzoate→diethoxymethane→methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→4-bromo-2-fluoro-1-iodobenzene→potassium 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate→(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazol-6-yl)(1H-imidazol-1-yl)methanone→O-(2-(tert-butoxy)ethyl)hydroxylamine→5-((4-bromo-2-fluorophenyl)amino)-N-(2-(tert-butoxy)ethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide hydrate
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