CAS 288-13-1

1,2-Diazole1H-pyrazole

Codes: (XXIX)1024528-1-c, CRIT-021, PALOV-010

Application context (from source-drug indications)

Non-small cell lung cancerPralsetinibThyroid cancerPralsetinibMedullary thyroid cancerPralsetinibPrimary cutaneous anaplastic large cell lymphomaCrizotinibAnaplastic large cell lymphomaCrizotinibNon-small cell lung cancerCrizotinibSchwannomaCrizotinibNeurofibromatosis type IICrizotinibMultiple myelomaCrizotinib进行性肌肉骨化症PalovaroteneHepatic function declinePalovarotene异位骨化Palovarotene遗传性多发性外生骨疣PalovaroteneDry eye syndromePalovaroteneEmphysemaPalovarotene

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Pralsetinib	Tier C — Watch / trade	2031
Crizotinib	Tier C — Watch / trade	-
Palovarotene	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

PralsetinibOptimised routesteps: 7total yield: /

1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one→4-Fluoro-1H-pyrazole→2,2,3,3-Tetrafluoropropan-1-ol→4-(2,2,3,3-Tetrafluoropropyl)morpholine→4-Methyl-4-(2,2,3,3-tetrafluoropropyl)morpholin-4-ium mesylate→1,2-Diazole→4-Methyl-4-[(1Z)-2,3,3-trifluoroprop-1-en-1-yl]morpholin-4-ium methanesulfonate→(2Z)-2-Fluoro-3-(morpholin-4-yl)prop-2-enal→Hydrazine dihydrochloride→4-Fluoro-1H-pyrazole hydrogen chloride→5-Bromo-2-chloropyridine→Acetic acid acetic anhydride→1-(6-Chloropyridin-3-yl)ethanone

CrizotinibOptimised routesteps: 3total yield: 22.5 g

1H-pyrazole→4-chloropyridine hydrochloride→4-(1H-pyrazol-1-yl)pyridine hydrochloride→4-(1H-pyrazol-1-yl)piperidine→4-(4-iodo-1H-pyrazol-1-yl)piperidine

PalovaroteneOriginator routesteps: 8total yield: 25.9 g

2,5-dimethylhexane-2,5-diol→2,5-dichloro-2,5-dimethylhexane→1-bromo-2-methylbenzene→6-bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene→3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile→3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbaldehyde→methyl 4-((dimethoxyphosphoryl)methyl)benzoate→(E)-methyl 4-(2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate→(E)-methyl 4-(2-(3-(bromomethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate→1H-pyrazole→(E)-methyl 4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazol-1-yl]piperidine-1-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	[5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin -2- yl]amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-amino-5-bromopyridin-3-ol Pharmaceutical Intermediates	On request	On request	On request	—

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