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CAS 290835-85-7
1-(2,6-dichloro-3-fluorophenyl)ethan-1-one
Codes: CRIT-001
Application context (from source-drug indications)
Primary cutaneous anaplastic large cell lymphomaCrizotinibAnaplastic large cell lymphomaCrizotinibNon-small cell lung cancerCrizotinibSchwannomaCrizotinibNeurofibromatosis type IICrizotinibMultiple myelomaCrizotinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Crizotinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2,6-dichloro-3-fluorophenyl)ethan-1-one→1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol→1-(2,6-dichloro-3-fluorophenyl)ethyl acetate→(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate→(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol→2-nitropyridin-3-ol→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→CRIT-010→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→CRIT-012→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine→tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl (R)-4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
1-(2,6-dichloro-3-fluorophenyl)ethan-1-one→(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazol-1-yl]piperidine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin -2- yl]amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-amino-5-bromopyridin-3-ol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.