CAS 2927-71-1

2,4-dichloro-5-fluoropyrimidine

Codes: ABEM-008, VORI-009

Application context (from source-drug indications)

Breast cancerAbemaciclibFungal infectionVoriconazoleCandidaemiaVoriconazoleCandidiasisVoriconazoleAspergillus infectionVoriconazole新型隐球菌感染Voriconazole镰刀菌感染Voriconazole

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Abemaciclib	Tier A — Act now	2029
Voriconazole	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

AbemaciclibOriginator routesteps: 9total yield: 20.4 g

propan-2-amine→N-isopropylacetamide→4-bromo-2,6-difluoroaniline→(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide→6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine→1-ethylpiperazine→6-bromonicotinaldehyde→1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

AbemaciclibOptimised routesteps: 3total yield: /

4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→1-ethylpiperazine→6-aminonicotinaldehyde→6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

VoriconazoleOptimised routesteps: 9total yield: 7.6 g

4-chloro-6-ethyl-5-fluoropyrimidine→1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one→2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol→5-fluoropyrimidine→2,4-dichloro-5-fluoropyrimidine→2,4-dichloro-6-ethyl-5-fluoropyrimidine→4-((l5-azanyl)oxy)-2-chloro-6-ethyl-5-fluoropyrimidine→6-ethyl-5-fluoropyrimidin-4-ol→4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine→3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	2,4-Dichloro-5-fluoropyrimidine Pharmaceutical Intermediates	On request	On request	On request	—

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