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CAS 29489-04-1
4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
Codes: CONI-010
Application context (from source-drug indications)
HyponatraemiaConivaptan HydrochlorideAcute decompensated heart failureConivaptan HydrochlorideHeart failureConivaptan HydrochlorideLiver diseaseConivaptan HydrochlorideTraumatic brain injuryConivaptan HydrochlorideKidney diseaseConivaptan Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Conivaptan Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
acetimidamide hydrochloride→1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→4-nitrobenzoic acid→(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)(4-nitrophenyl)methanone→(4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)methanone→[1,1'-biphenyl]-2-carbonyl chloride
[1,1'-biphenyl]-2-carboxylic acid→acetimidamide hydrochloride→1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine→4-aminobenzoic acid→4-([1,1'-biphenyl]-2-carboxamido)benzoic acid→pyridine hydrobromide→2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine hydrate
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