CAS 2974-94-9

1-Iodo-4-phenoxybenzene

Codes: (IIa)461018-14-a

Application context (from source-drug indications)

Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ibrutinib	Tier A — Act now	2027

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

IbrutinibOptimised routesteps: 2total yield: /

1H-Pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-Iodo-4-phenoxybenzene→(4-Phenoxyphenyl)boranediol→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→(3S)-Piperidin-3-ol--hydrogen chloride (1→2-Propenoic acid

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