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CAS 2986-19-8
methyl carbamimidothioate
Codes: AVAN-002, DECI-002, AZAC-002
Application context (from source-drug indications)
Erectile dysfunctionAvanafilAllergic reactionDecitabineCycloplegiaDecitabineHypotensionDecitabineAcute myeloid leukaemiaDecitabineMyelodysplastic syndromeDecitabineDiffuse large B-cell lymphomaDecitabine幼年型粒单核细胞白血病AzacitidineAcute myeloid leukaemiaAzacitidineMyelodysplastic syndromeAzacitidineChronic myeloid leukaemiaAzacitidineChronic myelomonocytic leukaemiaAzacitidine脑性瘫痪Azacitidine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Avanafil | Tier C — Watch / trade | 2028 |
| Decitabine | Tier C — Watch / trade | - |
| Azacitidine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
diethyl 2-(ethoxymethylene)malonate→methyl carbamimidothioate→ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate→(3-chloro-4-methoxyphenyl)methanamine hydrochloride→ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate→(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→(S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid→pyrimidin-2-ylmethanamine hydrochloride
((2R,3S)-3-acetoxy-5-isocyanatotetrahydrofuran-2-yl)methyl acetate→methyl carbamimidothioate→((2R,3S)-3-acetoxy-5-(3-((E)-amino(methylthio)methylene)ureido)tetrahydrofuran-2-yl)methyl acetate→methanetriol→((2R,3S,5R)-3-acetoxy-5-(4-(methylthio)-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-isocyanatotetrahydrofuran-3,4-diyl diacetate→methyl carbamimidothioate→(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(3-((E)-amino(methylthio)methylene)ureido)tetrahydrofuran-3,4-diyl diacetate→(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-(methylthio)-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
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