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CAS 30163-03-2

(S)-2-hydroxy-3-mercaptopropanoic acid

Codes: LAMI-010

Application context (from source-drug indications)

HIV infectionDolutegravir/Lamivudine/Tenofovir AlafenamideHIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHepatitis BLamivudineChronic hepatitis BLamivudineHIV infectionLamivudineRett syndromeLamivudineAlzheimer's diseaseLamivudineRetinal detachmentLamivudine

Source drugs (routes using this intermediate)

DrugTierExpiry
Dolutegravir/Lamivudine/Tenofovir AlafenamideTier C — Watch / trade-
Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
LamivudineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Dolutegravir/Lamivudine/Tenofovir AlafenamideOptimised routesteps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
LamivudineOptimised routesteps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.