CAS 309956-78-3

(R)-tert-butyl piperidin-3-ylcarbamate

Codes: LINA-006, ALOG-014, FOTAG-007

Application context (from source-drug indications)

Type 2 diabetesLinagliptinType 2 diabetesAlogliptin BenzoateDiabetesAlogliptin BenzoateAcute coronary syndromeAlogliptin BenzoateType 2 diabetesFultagliptin BenzoateRenal impairmentFultagliptin Benzoate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Linagliptin	Tier C — Watch / trade	2029
Alogliptin Benzoate	Tier C — Watch / trade	-
Fultagliptin Benzoate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LinagliptinOriginator routesteps: 4total yield: /

8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione→1-bromobut-2-yne→8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→(R)-tert-butyl piperidin-3-ylcarbamate→tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate

Alogliptin BenzoateOptimised routesteps: 5total yield: /

2-(aminomethyl)benzonitrile hydrochloride→1-(2-cyanobenzyl)-3-methylurea→diethyl malonate→2-((6-hydroxy-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-tert-butyl piperidin-3-ylcarbamate→tert-butyl (R)-(1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate

Fultagliptin BenzoateOriginator routesteps: 9total yield: 42.4 g

1-bromo-2-(bromomethyl)-4-fluorobenzene→1-bromo-4-fluoro-2-(isothiocyanatomethyl)benzene→N-(2-bromo-5-fluorobenzyl)hydrazinecarbothioamide→(Z)-methyl 2-(2-((2-bromo-5-fluorobenzyl)carbamothioyl)hydrazono)propanoate→4-(2-bromo-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one→4-(2-bromo-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one→(R)-tert-butyl piperidin-3-ylcarbamate→(R)-tert-butyl (1-(4-(2-bromo-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-yl)carbamate→(R)-tert-butyl (1-(4-(2-cyano-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-yl)carbamate→(R)-2-((3-(3-aminopiperidin-1-yl)-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl)methyl)-4-fluorobenzonitrile→Fotagliptin Benzoate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	(R)-3-(Boc-Amino)piperidine Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.