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CAS 31374-18-2
7-chloroquinazolin-4(3H)-one
Codes: AFAT-011
Application context (from source-drug indications)
Non-small cell lung cancerAfatinib DimaleateHead and neck squamous cell carcinomaAfatinib DimaleateHead and neck cancerAfatinib DimaleateChordomaAfatinib DimaleateSquamous cell carcinomaAfatinib DimaleateGallbladder cancerAfatinib Dimaleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Afatinib Dimaleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→2-amino-4-chlorobenzoic acid→7-chloroquinazolin-4(3H)-one→7-chloro-6-nitroquinazolin-4(4aH)-one→4,7-dichloro-6-nitroquinazoline→N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine→2-(diethoxyphosphoryl)acetic acid→(S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate→2,2-diethoxy-N,N-dimethylethanamine→maleic acid
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