CAS 320-51-4

4-chloro-3-(trifluoromethyl)aniline

Codes: SORF-007

Application context (from source-drug indications)

Thyroid cancerSorafenib TosylateHepatocellular carcinomaSorafenib TosylateRenal cell carcinomaSorafenib TosylateAggressive fibromatosisSorafenib TosylateLiver cancerSorafenib TosylateMyeloproliferative neoplasmSorafenib Tosylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Sorafenib Tosylate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Sorafenib TosylateOriginator routesteps: 5total yield: 118.19 g

picolinic acid→4-chloropicolinoyl chloride hydrochloride→4-chloropicolinoyl chloride→4-aminophenol→4-(4-aminophenoxy)-N-methylpicolinamide→1-chloro-4-isocyanato-2-(trifluoromethyl)benzene→4-chloro-3-(trifluoromethyl)aniline

Sorafenib TosylateOptimised routesteps: 3total yield: 32 g

4-chloropicolinoyl chloride→4-aminophenol→4-chloro-3-(trifluoromethyl)aniline→1-(4-hydroxyphenyl)urea→1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea

Sorafenib TosylateOptimised routesteps: 1total yield: 2.21 g

4-(4-aminophenoxy)-N-methylpicolinamide→4-chloro-3-(trifluoromethyl)aniline

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Pharmaceutical Intermediates	On request	On request	On request	—

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