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CAS 320347-97-5
(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate
Codes: ACLI-005
Application context (from source-drug indications)
Chronic obstructive pulmonary diseaseAclidinium Bromide/Formoterol Fumarate DihydrateChronic obstructive pulmonary diseaseAclidinium Bromide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Aclidinium Bromide/Formoterol Fumarate Dihydrate | Tier C — Watch / trade | - |
| Aclidinium Bromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene
Intermediates available on this site
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