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CAS 3272-08-0
4-hydroxy-3-nitrobenzonitrile
Codes: AFAT-028, FEBU-002
Application context (from source-drug indications)
Non-small cell lung cancerAfatinib DimaleateHead and neck squamous cell carcinomaAfatinib DimaleateHead and neck cancerAfatinib DimaleateChordomaAfatinib DimaleateSquamous cell carcinomaAfatinib DimaleateGallbladder cancerAfatinib DimaleateHyperuricaemiaFebuxostatGoutFebuxostatIntracranial haemorrhageFebuxostatUlcerative colitisFebuxostatChronic renal impairmentFebuxostatPainFebuxostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Afatinib Dimaleate | Tier C — Watch / trade | - |
| Febuxostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(E)-4-(dimethylamino)but-2-enoyl chloride→4-hydroxybenzonitrile→4-hydroxy-3-nitrobenzonitrile→(S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
4-hydroxy-3-nitrobenzaldehyde→4-hydroxy-3-nitrobenzonitrile→4-hydroxy-3-nitrobenzothioamide→ethyl 2-chloro-3-oxobutanoate→ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→1-bromo-2-methylpropane→ethyl 2-(4-isobutoxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.