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CAS 359-83-1

(2R,6R,11R)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocin-8-ol

Source drugs (routes using this intermediate)

DrugTierExpiry
PentazocineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

PentazocineOptimised routesteps: 9total yield: /
2-(4-methoxyphenyl)acetaldehyde→1-(4-benzyl-2-thioxothiazolidin-3-yl)propan-1-one→(2S,3R)-3-hydroxy-N-methoxy-4-(4-methoxyphenyl)-N,2-dimethylbutanamide→(3S,4R)-4-((tert-butyldimethylsilyl)oxy)-5-(4-methoxyphenyl)-3-methylpentan-2-one→(2R,3R)-1-(4-methoxyphenyl)-3,4-dimethylpent-4-en-2-ol→1-((2R,3R)-2-azido-3,4-dimethylpent-4-en-1-yl)-4-methoxybenzene→N-((2R,3R)-1-(4-methoxyphenyl)-3,4-dimethylpent-4-en-2-yl)-4-methylbenzenesulfonamide→#8→(2R,6R,11R)-8-methoxy-6,11-dimethyl-3-tosyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocine→(2R,6R,11R)-8-methoxy-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocine→(2R,6R,11R)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocin-8-ol

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