CAS 36653-82-4

hexadecan-1-ol1-Hexadecanol

Codes: CETI-001, Miltefosine-004

Application context (from source-drug indications)

ObesityCetilistatType 2 diabetesCetilistat利什曼原虫感染Miltefosine皮肤利什曼病MiltefosineChronic urticariaMiltefosine内脏利什曼病Miltefosine粘膜皮肤利什曼病Miltefosine

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Cetilistat	Tier C — Watch / trade	-
Miltefosine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

CetilistatOriginator routesteps: 2total yield: 2.51 g

hexadecan-1-ol→hexadecyl carbonochloridate→2-amino-5-methylbenzoic acid

CetilistatOptimised routesteps: 4total yield: 3.3 g

hexadecan-1-ol→1-isocyanato-4-methylbenzene→hexadecyl p-tolylcarbamate→hexadecyl (2-bromo-4-methylphenyl)carbamate→2-(((hexadecyloxy)carbonyl)amino)-5-methylbenzoic acid

MiltefosineOptimised routesteps: 4total yield: /

1-Hexadecanol→(Hexadecyloxy)phosphonoyl dichloride→2-(Hexadecyloxy)-1,3,2-oxazaphospholidin-2-one→hexadecyl propyl phosphate→1-Amino-2-hydroxyethane

MiltefosineOptimised routesteps: 2total yield: /

1-Hexadecanol→2-Chloro-1,3-dioxaphospholan-2-one→2-(hexadecyloxy)-1,3,2-dioxaphospholan-2-one

MiltefosineOptimised routesteps: 3total yield: 1.65g(Miltefosine (Free))

1-Hexadecanol→2-Chloro-1,3,2-dioxaphospholane→2-(hexadecyloxy)-1,3,2-dioxaphospholane→(2-bromoethyl) hexadecyl bromophosphonate→Dimethylamino methane

MiltefosineOptimised routesteps: 4total yield: /

1-Cyano-2-hydroxyethane→2-Cyanoethyl phosphorodichloridoite→Bis(isopropyl)amine→2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite→2-Hydroxy-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)→2-([(2-Cyanoethoxy)[di(propan-2-yl)amino]phosphanyl]oxy)-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)→1-Hexadecanol

Intermediates available on this site

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